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KMID : 1009020190170040559
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Clinical Psychopharmacology and Neuroscience
2019 Volume.17 No. 4 p.559 ~ p.563
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Efficacy of Asenapine in Schizophrenia Resistant to Clozapine Combined with Electroconvulsive Therapy: A Case Report
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Ochi Shinichiro
Inoue Saori
Yoshino Yuta
Shimizu Hideaki
Iga Jun-ichi
Ueno Shu-ichi
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Abstract
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Schizophrenic patients resistant to antipsychotics are diagnosed as having treatment-refractory schizophrenia, and they are treated with clozapine. However, clozapine is sometimes combined with electroconvulsive therapy (ECT) if clozapine monotherapy fails. In this report, a severe treatment-refractory schizophrenic patient who did not respond to clozapine even with ECT, but who recovered with asenapine monotherapy, is presented. Asenapine, considered a serotonin spectrum dopamine modulator, is a new atypical antipsychotic with unique pharmacological features that is used not only for schizophrenia, but also for bipolar disorder. The unique features of asenapine may be effective for some treatment-refractory schizophrenic patients.
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KEYWORD
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Asenapine, Treatment-refractory schizophrenia, Clozapine, Electroconvulsive therapy, Suicide, Recurrence
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